Download BookThe p53 Protein From Cell Regulation to Cancer (Cold Spring Harbor Perspectives in Medicine)

[Download PDF.y6RU] The p53 Protein From Cell Regulation to Cancer (Cold Spring Harbor Perspectives in Medicine)

[Download PDF.y6RU] The p53 Protein From Cell Regulation to Cancer (Cold Spring Harbor Perspectives in Medicine)

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Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a "guardian of the genome," protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in-and sometimes even promotes-human cancer.Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signals that trigger its activation or repression, and its downstream effects on genome stability and the cell cycle that enforce tumor suppression in different cell and tissue types. They also discuss how p53 dysfunction contributes to cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the prognostic value and clinical outcomes of these mutations. Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease. IJMS December 2015 - Browse Articles Despite advances in stem cell biology there are few effective techniques to promote the osteogenic differentiation of human primary dedifferentiated fat (DFAT) cells. Oxidants antioxidants and the current incurability of ... 5. The gene transcription activator Myc allows cells to move through the cell cycle. Long thought to be a key if not the key protein against which to develop cell ... Genentech: Vishva Dixit Vice President and Staff ... My laboratory primarily studies cell death and inflammation. More recently we've also become interested in the role of ubiquitin hydrolases as regulators of these and ... AP 1 Animations - Anatomy and Physiology Resources Anatomy & Physiology I Animations Movies & Interactive Tutorial Links "Pleasure in the job puts perfection in the work." - Aristotle. Genes & Development Preview contents abstracts since 1987 with PDF available to subscribers. Includes article search review collection and online submission to Cold Spring Harbor ... Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory - Founded in 1890 CSHL is a private non-profit institution with research programs in cancer neuroscience plant biology genomics ... Cold Spring Harbor Perspectives in Biology Cold Spring Harbor Perspectives in Biology a new online publication spanning the complete spectrum of the molecular life sciences. Each issue includes reviews ... TP53 - Wikipedia Identifiers BCC7 LFS1 P53 TRP53 tumor protein p53: External IDs: Genetically Related Diseases; basal cell carcinoma ... Assessing mutant p53 in primary high-grade serous ovarian ... The tumour suppressor p53 is mutated in cancer including over 96% of high-grade serous ovarian cancer (HGSOC). Mutations cause loss of wild-type p53 function due to ... Adenomatous polyposis coli - Wikipedia Identifiers BTPS2 DP2 DP2.5 DP3 GS PPP1R46 adenomatous polyposis coli WNT signaling pathway regulator: External IDs ...
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